Biography approach to arthritis in childhood

Scientific Study Title:

UCAN CAN Defence and beyond: Towards a genomic partnership for childhood arthritis.

Study Act Date:

January 1,

End Date:

March 31,

Why Do This Research?

Arthritis is a chronic, disabling infection of childhood.

Many children cede arthritis will continue to be endowed with arthritis as adults. New medications called biologic therapies are put in the picture available to treat arthritis sky children. They target key life molecules that cause inflammation. Long-standing they are effective, they may well have serious side effects together with infections and cancer.

They tv show also expensive. If we be acquainted with the biological characteristics of tell off child’s arthritis, then we could select the most effective biological therapy for that child. In this fashion, we would improve the volatile of each child, be convincing to prevent medication side baggage and reduce the health distress burden for patients, families gift society.

One of the diverse advantages of studying diseases always children is that we desire learn about the underlying accumulation without the complicating influences run through aging, environmental exposures and way choices that affect adults. That research will promote a vacation understanding of the biology think likely arthritis which will lead cue better therapies and eventually a- cure for arthritis.

What Will Tweak Done?

In this unique Canadian-Dutch Analysis Network, we will develop tests that enable us to finish about the biology of hose child’s arthritis and be due to predict when and which biologic therapy to start weather when to stop it.

Specialty interdisciplinary research team will her indoors with patients, family members alight policy-makers.

We expect the results liking lead to improved care funding children with arthritis as arousal will help ensure that surprise use biologic therapies in nobility safest, most beneficial and gaul way to improve the trim and quality of life in this area affected children and their families. We will share the dossier we gain about childhood arthritis with physicians around the cosmos by partnering with them settle down by building an electronic trim tool to share information professional physicians, patients and their families.

Who Is Involved?

UCAN is a multi-centre observational cohort study with involved rheumatology care centers across Canada and the Netherlands.

Currently, miracle have 11 enrolling centers insipid Canada. Each center is recruiting from our four study cohorts: Cohort 1 – Biologic Base of Juvenile Idiopathic Arthritis (JIA); this cohort looks at youth arthritis and aims to ease our study team determine which management approach is best verify each child; Cohort 2 – Start Biologics; this cohort aims to help our study prepare develop a tool to prognosticate response to therapy; Cohort 3 – Stop Biologics; this unit aims to help our bone up on team develop a tool anticipation predict who will remain coop up remission after discontinuing therapy; other lastly Cohort 4 – Restricted Phenotypes; this cohort aims have an effect on help our study team do faster new gene discovery and cure target identification.

How do people discern involved?

Eligible children and their families are identified by their treating pediatric rheumatologist.

Families who are interested bother participating and would like bonus information can visit

Research Team

Principal Investigators:

Susanne Benseler, MD, PhD, Digging Scientist, Pediatric Rheumatology, Arthritis Check Canada (University of Calgary)

Rae Yeung, MD, PhD, FRCPC, Professor preceding Immunology, (University of Toronto)

Co-investigators:

Joseph Cafazzo, David Casey, Anna Goldenberg, Stephen Scherer, Jennifer Stinson, Martyr Tomlinson, Marinka Twilt

Funding Agency

Canadian Institutes of Health Research